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Monounsaturated Fatty Acids in Obesity-Related Inflammation.
Ravaut G, Légiot A, Bergeron KF, Mounier C. Ravaut G, et al. Int J Mol Sci. 2020 Dec 30;22(1):330. doi: 10.3390/ijms22010330. Int J Mol Sci. 2020. PMID: 33396940 Free PMC article. Review.
In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflammatory cytokines. Interleukin-1beta secretion, sustained C-react …
In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) lead …
The interplay between the gut microbiota and NLRP3 activation affects the severity of acute pancreatitis in mice.
Li X, He C, Li N, Ding L, Chen H, Wan J, Yang X, Xia L, He W, Xiong H, Shu X, Zhu Y, Lu N. Li X, et al. Gut Microbes. 2020 Nov 1;11(6):1774-1789. doi: 10.1080/19490976.2020.1770042. Epub 2020 Jun 12. Gut Microbes. 2020. PMID: 32529941 Free PMC article.
Although the gut barrier in GF and Abx mice was disrupted, gut microbiota deficiency ameliorated the severity of AP, probably due to the reduction in bacterial translocation from the gut to the pancreas. The composition of the gut microbiota was significantly different bet …
Although the gut barrier in GF and Abx mice was disrupted, gut microbiota deficiency ameliorated the severity of AP, probably due to the red …
Inflammation as a link between obesity, metabolic syndrome and type 2 diabetes.
Esser N, Legrand-Poels S, Piette J, Scheen AJ, Paquot N. Esser N, et al. Diabetes Res Clin Pract. 2014 Aug;105(2):141-50. doi: 10.1016/j.diabres.2014.04.006. Epub 2014 Apr 13. Diabetes Res Clin Pract. 2014. PMID: 24798950 Free article. Review.
Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, liver, muscle and pancreas are themselves sites of inflammation in presence of obesity. ...Particularly, the pro-inflammatory interleu …
Systemic inflammatory markers are risk factors for the development of type 2 diabetes and its macrovascular complications. Adipose tissue, l …
NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis.
Sendler M, van den Brandt C, Glaubitz J, Wilden A, Golchert J, Weiss FU, Homuth G, De Freitas Chama LL, Mishra N, Mahajan UM, Bossaller L, Völker U, Bröker BM, Mayerle J, Lerch MM. Sendler M, et al. Gastroenterology. 2020 Jan;158(1):253-269.e14. doi: 10.1053/j.gastro.2019.09.040. Epub 2019 Oct 5. Gastroenterology. 2020. PMID: 31593700 Free article.
METHODS: We induced severe acute pancreatitis by partial duct ligation with caerulein stimulation or intraperitoneal injection of l-arginine in mice with deletion of interleukin (IL)12B, NLRP3, or IL18 and in mice given MCC950, a small molecule inhibitor of the NLRP3 …
METHODS: We induced severe acute pancreatitis by partial duct ligation with caerulein stimulation or intraperitoneal injection of l-arginine …
Butyrate ameliorates caerulein-induced acute pancreatitis and associated intestinal injury by tissue-specific mechanisms.
Pan X, Fang X, Wang F, Li H, Niu W, Liang W, Wu C, Li J, Tu X, Pan LL, Sun J. Pan X, et al. Br J Pharmacol. 2019 Dec;176(23):4446-4461. doi: 10.1111/bph.14806. Epub 2019 Dec 8. Br J Pharmacol. 2019. PMID: 31347703 Free PMC article.
Amelioration of pancreatic damage by butyrate was associated with reduced levels of TNF-alpha, IL-6, and CCL2 and suppressed activation of the NLRP3 inflammasome in both pancreas and colon. Further, butyrate ameliorated pancreatic inflammation by suppressing interac …
Amelioration of pancreatic damage by butyrate was associated with reduced levels of TNF-alpha, IL-6, and CCL2 and suppressed activation of t …
S1P/S1PR2 promote pancreatic stellate cell activation and pancreatic fibrosis in chronic pancreatitis by regulating autophagy and the NLRP3 inflammasome.
Cui L, Li C, Zhang G, Zhang L, Yao G, Zhuo Y, Cui N, Zhang S. Cui L, et al. Chem Biol Interact. 2023 Aug 1;380:110541. doi: 10.1016/j.cbi.2023.110541. Epub 2023 May 9. Chem Biol Interact. 2023. PMID: 37169277
When S1P was administered to CP rats, the function and histomorphology of the pancreas were severely impaired. In addition, S1P promoted PSC activation, heightened autophagy and enhanced the NLRP3 inflammasome in vivo and in vitro. Moreover, S1PR2 mediated the effec …
When S1P was administered to CP rats, the function and histomorphology of the pancreas were severely impaired. In addition, S1P promo …
Fatty Acids and NLRP3 Inflammasome-Mediated Inflammation in Metabolic Tissues.
Ralston JC, Lyons CL, Kennedy EB, Kirwan AM, Roche HM. Ralston JC, et al. Annu Rev Nutr. 2017 Aug 21;37:77-102. doi: 10.1146/annurev-nutr-071816-064836. Annu Rev Nutr. 2017. PMID: 28826373 Review.
The NLRP3 inflammasome can be influenced by various metabolites, including fatty acids. Specifically, although saturated fatty acids may promote NLRP3 inflammasome activation, monounsaturated fatty acids and polyunsaturated fatty acids have recently been shown to im …
The NLRP3 inflammasome can be influenced by various metabolites, including fatty acids. Specifically, although saturated fatty acids …
Combinatory antibiotic treatment protects against experimental acute pancreatitis by suppressing gut bacterial translocation to pancreas and inhibiting NLRP3 inflammasome pathway.
Jia L, Chen H, Yang J, Fang X, Niu W, Zhang M, Li J, Pan X, Ren Z, Sun J, Pan LL. Jia L, et al. Innate Immun. 2020 Jan;26(1):48-61. doi: 10.1177/1753425919881502. Epub 2019 Oct 15. Innate Immun. 2020. PMID: 31615312 Free PMC article.
The protective effect was also confirmed by improved histological morphology of the pancreas and decreased pro-inflammatory markers (IL-1beta, TNF-alpha, MCP-1) in pancreas. ...Together, combinatory ABX therapy inhibited the translocation of gut bacteria to pancr …
The protective effect was also confirmed by improved histological morphology of the pancreas and decreased pro-inflammatory markers ( …
Tumor Cell-Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer.
Das S, Shapiro B, Vucic EA, Vogt S, Bar-Sagi D. Das S, et al. Cancer Res. 2020 Mar 1;80(5):1088-1101. doi: 10.1158/0008-5472.CAN-19-2080. Epub 2020 Jan 8. Cancer Res. 2020. PMID: 31915130 Free PMC article.
Tumor cell expression of IL1beta in vivo was driven by microbial-dependent activation of toll-like receptor 4 (TLR4) signaling and subsequent engagement of the NLRP3 inflammasome. Collectively, these findings identify a hitherto unappreciated role for tumor cell-derived IL …
Tumor cell expression of IL1beta in vivo was driven by microbial-dependent activation of toll-like receptor 4 (TLR4) signaling and subsequen …
Cashew (Anacardium occidentale L.) Nuts Modulate the Nrf2 and NLRP3 Pathways in Pancreas and Lung after Induction of Acute Pancreatitis by Cerulein.
Cordaro M, Fusco R, D'Amico R, Siracusa R, Peritore AF, Gugliandolo E, Genovese T, Crupi R, Mandalari G, Cuzzocrea S, Di Paola R, Impellizzeri D. Cordaro M, et al. Antioxidants (Basel). 2020 Oct 14;9(10):992. doi: 10.3390/antiox9100992. Antioxidants (Basel). 2020. PMID: 33066525 Free PMC article.
While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on nuclear factor E2-related factor 2 (Nrf2) and nucleotide-binding domain leucine-rich repeat (NLR) and pyrin domain containing receptor 3 ( …
While many aspects of AP-induced lung inflammation have been investigated, the involvement of specific pathways, such as those centered on n …
148 results